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Claudiu T Supuran Selected Research

sulfamic acid (ammonium sulfamate)

11/2019Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells.
2/2017New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs.
9/2014Cyclic tertiary sulfamates: selective inhibition of the tumor-associated carbonic anhydrases IX and XII by N- and O-substituted acesulfame derivatives.
1/2014Sulfonamide inhibition studies of the γ-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis.
1/2014Tumor microenvironmental changes induced by the sulfamate carbonic anhydrase IX inhibitor S4 in a laryngeal tumor model.
11/2013Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates.
6/2012Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts.
1/2007Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.
3/2005Sulfamates and their therapeutic potential.
2/2005Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.
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Claudiu T Supuran Research Topics

Disease

542Neoplasms (Cancer)
12/2022 - 11/2002
84Glaucoma
12/2022 - 02/2002
68Hypoxia (Hypoxemia)
12/2022 - 06/2004
35Epilepsy (Aura)
01/2022 - 01/2007
34Breast Neoplasms (Breast Cancer)
12/2022 - 03/2005
34Neoplasm Metastasis (Metastasis)
04/2022 - 01/2010
28Obesity
12/2021 - 02/2004
23Neuralgia (Stump Neuralgia)
12/2022 - 04/2015
19Infections
12/2022 - 07/2002
19Carcinogenesis
12/2022 - 11/2005
19Alzheimer Disease (Alzheimer's Disease)
01/2021 - 01/2002
15Malaria
12/2022 - 01/2008
13Dandruff
12/2020 - 04/2012
13Chagas Disease (American Trypanosomiasis)
12/2020 - 02/2013
13Dehydration (Water Stress)
12/2019 - 10/2003
12Pain (Aches)
01/2022 - 01/2007
12Arthritis (Polyarthritis)
12/2020 - 01/2016
12Retinitis Pigmentosa (Pigmentary Retinopathy)
12/2019 - 01/2017
11Acidosis
12/2022 - 01/2008
11Carcinoma (Carcinomatosis)
01/2021 - 08/2006
10Seizures (Absence Seizure)
01/2021 - 01/2007
10Pathologic Processes
10/2020 - 08/2006
9Colonic Neoplasms (Colon Cancer)
12/2021 - 04/2009
9Rheumatoid Arthritis
01/2021 - 09/2003
8Melanoma (Melanoma, Malignant)
12/2020 - 10/2012
8Hypertension (High Blood Pressure)
05/2017 - 01/2008
8Weight Loss (Weight Reduction)
01/2013 - 03/2005
7Inflammation (Inflammations)
01/2021 - 01/2007
7Prostatic Neoplasms (Prostate Cancer)
12/2020 - 03/2005
6Colorectal Neoplasms (Colorectal Cancer)
12/2022 - 10/2017
6Altitude Sickness (Mountain Sickness)
01/2022 - 05/2010
6Edema (Dropsy)
01/2022 - 01/2016
6Nervous System Diseases (Neurological Disorders)
05/2020 - 03/2003
5Communicable Diseases (Infectious Diseases)
12/2022 - 02/2004
5Brain Ischemia (Cerebral Ischemia)
11/2021 - 12/2016
5Uterine Cervical Neoplasms (Cancer of the Cervix)
06/2021 - 12/2018
5Leishmaniasis
12/2019 - 09/2013
5Tuberculosis (Tuberculoses)
10/2019 - 01/2007
5Ocular Hypertension (Glaucoma, Suspect)
10/2019 - 06/2011
5Melioidosis
12/2018 - 01/2017

Drug/Important Bio-Agent (IBA)

413Carbonic Anhydrases (Carbonic Anhydrase)IBA
12/2022 - 02/2003
357Protein Isoforms (Isoforms)IBA
12/2022 - 08/2003
217SulfonamidesIBA
08/2022 - 10/2002
157IsoenzymesIBA
12/2022 - 02/2002
154EnzymesIBA
12/2022 - 02/2003
109Carbonic Anhydrase IXIBA
12/2022 - 03/2003
106Pharmaceutical PreparationsIBA
12/2022 - 09/2003
78Carbonic Anhydrase InhibitorsIBA
12/2022 - 03/2003
51BenzenesulfonamidesIBA
12/2022 - 04/2005
41Acetazolamide (Diamox)FDA LinkGeneric
12/2022 - 03/2003
41ZincIBA
12/2021 - 05/2003
34Proteins (Proteins, Gene)FDA Link
12/2022 - 06/2004
27CoumarinsIBA
12/2022 - 08/2010
26Antineoplastic Agents (Antineoplastics)IBA
12/2021 - 01/2004
26Anticonvulsants (Antiepileptic Drugs)IBA
01/2021 - 03/2003
25SLC-0111IBA
12/2022 - 03/2016
24Biological ProductsIBA
01/2022 - 02/2008
19coumarinIBA
01/2022 - 08/2010
16Bicarbonates (Hydrogen Carbonate)IBA
12/2022 - 11/2002
14AnionsIBA
07/2019 - 11/2002
12Protons (Proton)IBA
12/2022 - 06/2004
12Amino AcidsFDA Link
10/2021 - 08/2007
11DiureticsIBA
11/2021 - 08/2006
11sulfamic acid (ammonium sulfamate)IBA
11/2019 - 12/2003
10Anti-Bacterial Agents (Antibiotics)IBA
12/2022 - 03/2005
10Oxygen (Dioxygen)IBA
01/2022 - 06/2004
10Biomarkers (Surrogate Marker)IBA
12/2021 - 06/2007
10Doxorubicin (Adriamycin)FDA LinkGeneric
12/2021 - 01/2012
10dorzolamide (Trusopt)FDA LinkGeneric
04/2020 - 03/2003
9Carbon DioxideIBA
12/2022 - 06/2004
9Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
12/2020 - 01/2004
9AminesIBA
12/2018 - 08/2007
8ProdrugsIBA
06/2022 - 12/2013
8Oxaliplatin (Eloxatin)FDA LinkGeneric
01/2022 - 04/2015
8SulfanilamideFDA Link
01/2022 - 02/2004
8Carboxylic AcidsIBA
01/2022 - 12/2014
8AcidsIBA
12/2021 - 06/2014
8Topiramate (Topamax)FDA LinkGeneric
04/2020 - 03/2005
7Anti-Obesity Agents (Antiobesity Drugs)IBA
01/2021 - 08/2006
7Benzene (Benzole)IBA
05/2020 - 03/2008
7carbonic anhydrase XIIIBA
01/2019 - 06/2013
7Enzyme Inhibitors (Inhibitors, Enzyme)IBA
09/2017 - 02/2009
7Sulfhydryl Compounds (Thiols)IBA
01/2016 - 05/2005
7Antiglaucoma AgentsIBA
07/2012 - 08/2006
6Carbonic Anhydrase IIIBA
03/2021 - 06/2009
6Zonisamide (Zonegran)FDA LinkGeneric
04/2020 - 01/2007
6Celecoxib (Celebrex)FDA Link
04/2020 - 01/2015
6Hydro-Lyases (Dehydratases)IBA
03/2020 - 01/2007
6Transcription Factors (Transcription Factor)IBA
01/2018 - 11/2006
6CarbohydratesIBA
10/2014 - 11/2006
5Monoclonal AntibodiesIBA
12/2022 - 01/2012
5SaccharinIBA
08/2022 - 03/2014
5AcetylcholinesteraseIBA
12/2020 - 01/2019
5SaltsIBA
10/2020 - 04/2007
5LigandsIBA
12/2019 - 04/2014
5Antimalarials (Antimalarial Agents)IBA
12/2019 - 01/2007
5Matrix Metalloproteinases (MMPs)IBA
12/2017 - 09/2003

Therapy/Procedure

97Therapeutics
12/2022 - 01/2002
16Radiotherapy
12/2022 - 07/2005
14Drug Therapy (Chemotherapy)
12/2021 - 05/2003